Alex Duncan
Thomas, A. A.; Chien, H.-C.; Zur, A. A.; Giacomini, K. M.; Colas, C.; Schlessinger, A.; Lin, L.; Finke, K.; Augustyn, E.; Springer, S.; Stoner, L.; Flint, A.; Heeren, N.; Hansen, L.; Anthony, A.; Hernandez, C.; Venteicher, B.; Campbell, J.; Hall, C.
Springer, S.; Stoner, L.; Finke, K.; Anthony, A.; Flint, A.; Bauer, J.; Hernandez, C.; Chien, H.-C.; Giacomini, K. M.; Colas, C.; Schlessinger, A.; Thomas, A. A.
Venteicher, B.; Hall, C.; Campbell, J.; Hernandez, C.; Flint, A.; Chien, H.-C.; Giacomini, K. M.; Colas, C.; Schlessinger, A.; Thomas, A. A.
Hall, C.; Venteicher, B.; Chien, H.-C.; Giacomini, K. M.; Colas, C.; Schlessinger, A.; Thomas, A. A.
Brooklynn, Colton, Dr. Thomas, Seth
Brooklynn, Seth, Colton, Dr. Thomas
In 2017, Dr. Thomas received a National Institutes of Health (NIH) Academic Research Enhancement Award (AREA) through the National Institute of Neurological Disorders and Stroke (NINDS) for a project entitled “Identification of new LAT-1 transporter substrates for drug delivery” (R15 NS099981). His research group seeks to exploit one of the body’s natural mechanisms for transporting amino acids, the LAT-1 protein, for targeted drug delivery across the blood-brain barrier (BBB) and cancer cells that express this transporter. Guided by computational models developed in collaboration with Prof. Avner Schlessinger at Icahn School of Medicine at Mt. Sinai, students in the Thomas lab apply organic chemistry techniques to synthesize amino acid mimetics and drug-amino acid conjugates, which are then tested in cells engineered to express LAT-1 by his collaborator, Dr. Kathleen Giacomini at University California San Francisco. This research project has broad applications for treating many different diseases both in the brain and other tissues where LAT-1 is heavily expressed, including cancer.
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