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Thomas Research Group at UNK

Thomas Research Group at UNKThomas Research Group at UNKThomas Research Group at UNK

Most recent publication (2022)

Synthesis of ribavirin 1,2,3- and 1,2,4-triazolyl analogs with changes at the amide and cytotoxicity in breast cancer cell lines  (Way, H., et al.)

Four undergrads presented at the 2021 acs midwest meeting (Springfield, MO)

Hannah way presented on cnt2 inhibitors at virtual posters on the hill

Hannah Way was accepted into the prestigious Posters on the Hill, usually held in Washington, D.C.

    Five Undergrads presented at the 2019 acs midwest meeting in Wichita, KS

    Brooklynn presented our work in both poster and oral format at an undergraduate symposium at St Jude in June 2019

    Allen was featured in UNK's New Frontiers magazine

    Link to Magazine Article

    Nine undeRgrads Presented at the 2018 Midwest ACS Meeting in Ames, Iowa

    Alex Duncan

      ACS National Meeting in New Orleans, Spring 2018

      Oral Presentation: LAT1 membrane transporter: reevaluating the meaning of L and A

      Poster: Synthesis and SAR of alpha-quaternary phenylalanine analogs as LAT1 substrates

      Oral Presentation: LAT1 membrane transporter: reevaluating the meaning of L and A

       Thomas, A. A.; Chien, H.-C.; Zur, A. A.; Giacomini, K. M.; Colas, C.; Schlessinger, A.; Lin, L.; Finke, K.; Augustyn, E.; Springer, S.; Stoner, L.; Flint, A.; Heeren, N.; Hansen, L.; Anthony, A.; Hernandez, C.; Venteicher, B.; Campbell, J.; Hall, C. 

      Poster: Optimization of LAT1 affinity for meta-substituted phenylalanine analogs

      Poster: Synthesis and SAR of alpha-quaternary phenylalanine analogs as LAT1 substrates

      Oral Presentation: LAT1 membrane transporter: reevaluating the meaning of L and A

      Springer, S.; Stoner, L.; Finke, K.; Anthony, A.; Flint, A.; Bauer, J.; Hernandez, C.; Chien, H.-C.; Giacomini, K. M.; Colas, C.; Schlessinger, A.; Thomas, A. A. 

      Poster: Synthesis and SAR of alpha-quaternary phenylalanine analogs as LAT1 substrates

      Poster: Synthesis and SAR of alpha-quaternary phenylalanine analogs as LAT1 substrates

      Poster: Synthesis and SAR of alpha-quaternary phenylalanine analogs as LAT1 substrates

      Venteicher, B.; Hall, C.; Campbell, J.; Hernandez, C.; Flint, A.; Chien, H.-C.; Giacomini, K. M.; Colas, C.; Schlessinger, A.; Thomas, A. A. 

      Poster: LAT1 selectivity for L and D amino acids

      Poster: LAT1 selectivity for L and D amino acids

      Poster: Synthesis and SAR of alpha-quaternary phenylalanine analogs as LAT1 substrates

      Hall, C.; Venteicher, B.; Chien, H.-C.; Giacomini, K. M.; Colas, C.; Schlessinger, A.; Thomas, A. A. 

      Visiting Historic Sites

      Poster: LAT1 selectivity for L and D amino acids

      Enjoying New Orleans Cuisine

      Brooklynn, Colton, Dr. Thomas, Seth

      Enjoying New Orleans Cuisine

      Poster: LAT1 selectivity for L and D amino acids

      Enjoying New Orleans Cuisine

      Brooklynn, Seth, Colton, Dr. Thomas

      NIH Funding

      Identification of new LAT-1 transporter substrates for drug delivery

       In 2017, Dr. Thomas received a National Institutes of Health (NIH)  Academic Research Enhancement Award (AREA) through the National  Institute of Neurological Disorders and Stroke (NINDS) for a project  entitled “Identification of new LAT-1 transporter substrates for drug  delivery” (R15 NS099981). His research group seeks to exploit one of the  body’s natural mechanisms for transporting amino acids, the LAT-1  protein, for targeted drug delivery across the blood-brain barrier (BBB)  and cancer cells that express this transporter. Guided by computational  models developed in collaboration with Prof. Avner Schlessinger at  Icahn School of Medicine at Mt. Sinai, students in the Thomas lab apply  organic chemistry techniques to synthesize amino acid mimetics and  drug-amino acid conjugates, which are then tested in cells engineered to  express LAT-1 by his collaborator, Dr. Kathleen Giacomini at University  California San Francisco. This research project has broad applications  for treating many different diseases both in the brain and other tissues  where LAT-1 is heavily expressed, including cancer.

      NIH-R15 Funding - Dr. Thomas receives 399K award!


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