Recent Publications

Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1)

In collaboration with Professor Giacomini at UCSF and Professor Schlessinger at Icahn School of Medicine at Mt. Sinai, the Thomas group recently published our work in the Journal of Medicinal Chemistry  (July 2018). 

ACS National Meeting in New Orleans, Spring 2018

Oral Presentation: LAT1 membrane transporter: reevaluating the meaning of L and A

 Thomas, A. A.; Chien, H.-C.; Zur, A. A.; Giacomini, K. M.; Colas, C.; Schlessinger, A.; Lin, L.; Finke, K.; Augustyn, E.; Springer, S.; Stoner, L.; Flint, A.; Heeren, N.; Hansen, L.; Anthony, A.; Hernandez, C.; Venteicher, B.; Campbell, J.; Hall, C. 

Poster: Optimization of LAT1 affinity for meta-substituted phenylalanine analogs

Springer, S.; Stoner, L.; Finke, K.; Anthony, A.; Flint, A.; Bauer, J.; Hernandez, C.; Chien, H.-C.; Giacomini, K. M.; Colas, C.; Schlessinger, A.; Thomas, A. A. 

Poster: Synthesis and SAR of alpha-quaternary phenylalanine analogs as LAT1 substrates

Venteicher, B.; Hall, C.; Campbell, J.; Hernandez, C.; Flint, A.; Chien, H.-C.; Giacomini, K. M.; Colas, C.; Schlessinger, A.; Thomas, A. A. 

Poster: LAT1 selectivity for L and D amino acids

Hall, C.; Venteicher, B.; Chien, H.-C.; Giacomini, K. M.; Colas, C.; Schlessinger, A.; Thomas, A. A. 

Visiting Historic Sites

Brooklynn, Colton, Dr. Thomas, Seth

Enjoying New Orleans Cuisine

Brooklynn, Seth, Colton, Dr. Thomas

NIH Funding

Identification of new LAT-1 transporter substrates for drug delivery

 In 2017, Dr. Thomas received a National Institutes of Health (NIH)  Academic Research Enhancement Award (AREA) through the National  Institute of Neurological Disorders and Stroke (NINDS) for a project  entitled “Identification of new LAT-1 transporter substrates for drug  delivery” (R15 NS099981). His research group seeks to exploit one of the  body’s natural mechanisms for transporting amino acids, the LAT-1  protein, for targeted drug delivery across the blood-brain barrier (BBB)  and cancer cells that express this transporter. Guided by computational  models developed in collaboration with Prof. Avner Schlessinger at  Icahn School of Medicine at Mt. Sinai, students in the Thomas lab apply  organic chemistry techniques to synthesize amino acid mimetics and  drug-amino acid conjugates, which are then tested in cells engineered to  express LAT-1 by his collaborator, Dr. Kathleen Giacomini at University  California San Francisco. This research project has broad applications  for treating many different diseases both in the brain and other tissues  where LAT-1 is heavily expressed, including cancer.

NIH-R15 Funding - Dr. Thomas receives 399K award!